![]() Migraine attacks are characterized by unilateral pulsating frontotemporal moderate to severe pain lasting 4–72 h, and associated photophobia, phonophobia, nausea and vomiting. ![]() ![]() Migraine is a primary headache disorder hampering the quality of life of millions worldwide. Understanding the neurobiological mechanisms of this nociceptive window, may provide a novel target in migraine treatment. We suppose LVC triggered rapid-onset migraine-like symptoms are probably related to functional alterations in the trigeminal nociceptive system and K + channel opening properties of LVC. Single LVC administration induced the fastest manifestation and recovery of acute migraine-like phenotype which was not mediated by CSD waves in the cerebral cortex. Acute LVC or NTG injection did not increase cortical BBB permeability. Somatosensory evoked potential (SSEP) configurations were not altered in both LVC and NTG groups, but SSEP latencies were prolonged after CSD. However, NTG significantly increased both CSD susceptibility and propagation failure. LVC did not induce de novo CSD and affect KCl (potassium chloride)-induced CSD parameters except for an increase in propagation failure. Both LVC and NTG did not provoke DC (direct current) shift, EEG alterations or cortical c-fos expression characteristic to CSD. LVC induced migraine-like phenotype recovered in 2 h while NTG group did not fully recover before 4 h. LVC and NTG administration robustly reduced periorbital mechanical thresholds in rats and induced anxiety-like behaviors and photophobia within 30 and 120 min, respectively. Blood–brain barrier integrity in cortex was examined with Evans blue assay. Possible CSD-induced c-fos expression was studied with Western Blot. The effects of LVC on CSD parameters, somatosensory evoked potentials, and baseline dural EEG (electroencephalography) were investigated. Dark–light box (DLB), elevated plus maze (EPM), and open field arena (OFA) were used to evaluate light sensitivity and anxiety-related behaviors. Von Frey filaments were used to examine the periorbital and hind paw mechanical allodynia. Wistar rats were administered LVC (1 mg/kg, i.p.) and compared to control (CTRL, vehicle, i.p.) and nitroglycerin (NTG, 10 mg/kg, i.p.) groups. We investigated whether single LVC injection causes acute migraine-like phenotype in rats and induces/modulates cortical spreading depolarization (CSD), a rodent model of migraine aura. Shop the full line up of Aura frames at headache attacks and accompanying sensory augmentation can be induced by several agents including levcromakalim (LVC), that is also capable of provoking aura-like symptoms in migraineurs. No matter which frame you’ve got your eye on, Aura frames are a top choice to gift for any occasion as customers can pre-load any Aura frame with photos, videos, and a gift message in the app before it’s delivered for meaningful gifting from anywhere. Carver beautifully displays full landscape photos and intelligently pairs portrait photos side-by-side using smart curation software for delightful match-ups of life’s best moments. Find out if your local Target carries Aura in store here.Ĭarver features an updated landscape 10.1" HD 1280 x 800 display, each individually calibrated for color and brightness with an 89-degree viewing angle. Sutton and Warm Stone are available exclusively at Target online and in select retail stores. A perfect complement to nearly any home decor style the muted, warm tones of the frame were meticulously designed to look as if they were carved from stone. Target is also home to another exclusive finish: Warm Stone, a warm beige color with a hand-speckled, soft matte finish. Plus, we make it easy to update using the Aura app, giving memories more airtime and looking less like another piece of smart home tech.Įxplore these gorgeous new designs, all perfect for gifting to everyone on your holiday list. ![]() Whether on a mantle, bedside table, or kitchen counter, your Aura frame was designed to blend seamlessly into your home. Inspired by natural stone and premium metals, Aura frames put your favorite moments on display. Now you can browse new Aura frames styles as you stroll the aisles. We can all agree that a Saturday morning at Target is the ultimate form of self care. New landscape designs of our top-selling connected frames land this holiday, both online and in select Target stores - including Aura’s debut of exclusive colorways. Aura frames aren’t just any digital photo frame - our team of designers pour over the details of each WiFi-connected Aura frame, from their minimalist design aesthetic to their perfectly color-calibrated displays, so that every Aura frame looks perfectly at home in any home. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |